In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila

Antimicrob Agents Chemother. 2001 Apr;45(4):1281-3. doi: 10.1128/AAC.45.4.1281-1283.2001.

Abstract

The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated. Cefotaxime (4 times the MIC) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aeromonas hydrophila / drug effects*
  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Cefotaxime / pharmacology
  • Cefotaxime / therapeutic use*
  • Cephalosporins / pharmacology
  • Cephalosporins / therapeutic use*
  • Drug Synergism
  • Drug Therapy, Combination / pharmacology
  • Drug Therapy, Combination / therapeutic use*
  • Gram-Negative Bacterial Infections / drug therapy*
  • Kinetics
  • Mice
  • Microbial Sensitivity Tests
  • Minocycline / pharmacology
  • Minocycline / therapeutic use*
  • Survival Analysis

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Minocycline
  • Cefotaxime