Abstract
The sequences of the bla(TEM) genes encoding TEM-92 in Proteus mirabilis and Providencia stuartii isolates were determined and were found to be identical. Except for positions 218 (Lys-6) and 512 (Lys-104), the nucleotide sequence of bla(TEM-92) was identical to that of bla(TEM-20), including the sequence of the promoter region harboring a 135-bp deletion combined with a G-162-->T substitution. The deduced amino acid sequence of TEM-92 differed from that of TEM-52 by the presence of a substitution (Gln-6-->Lys) in the peptide signal.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Enterobacteriaceae Infections / drug therapy
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Enterobacteriaceae Infections / microbiology
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Genes, Bacterial
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Humans
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Microbial Sensitivity Tests
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Promoter Regions, Genetic
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Proteus Infections / drug therapy
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Proteus Infections / microbiology
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Proteus mirabilis / drug effects*
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Proteus mirabilis / enzymology*
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Proteus mirabilis / genetics
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Providencia / drug effects*
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Providencia / enzymology*
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Providencia / genetics
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Sequence Analysis, DNA
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beta-Lactam Resistance
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beta-Lactamases / genetics*
Substances
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beta-lactamase TEM-92
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beta-Lactamases