Abstract
Nontypable Haemophilus influenzae is a common cause of otitis media and initiates infection by colonizing the upper respiratory tract. In this article, I review our current understanding of the molecular determinants of H. influenzae colonization and discuss the relationship between colonization and otitis media.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adhesins, Bacterial / genetics
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Adhesins, Bacterial / physiology
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Adolescent
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Adult
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Antibodies, Bacterial / immunology
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Antigenic Variation
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Antigens, Bacterial / genetics
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Antigens, Bacterial / immunology
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Bacterial Adhesion
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / physiology
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Bacterial Typing Techniques
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Carrier State / epidemiology
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Carrier State / microbiology
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Child
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Child, Preschool
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Cilia / microbiology
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Fimbriae Proteins*
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Fimbriae, Bacterial / physiology
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Haemophilus Infections / epidemiology
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Haemophilus Infections / microbiology*
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Haemophilus influenzae / classification
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Haemophilus influenzae / genetics
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Haemophilus influenzae / immunology
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Haemophilus influenzae / pathogenicity*
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Humans
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Immunoglobulin A / immunology
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Infant
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Lipopolysaccharides / metabolism
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Mucus / microbiology
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Operon / genetics
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Otitis Media / microbiology*
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Point Mutation
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Serine Endopeptidases / physiology
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Species Specificity
Substances
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Adhesins, Bacterial
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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HMW1 protein, bacteria
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HMW2 protein, bacteria
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Hap protein, Hemophilus influenzae
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Hia adhesin
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HifA protein, Haemophilus influenzae
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Immunoglobulin A
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Lipopolysaccharides
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Fimbriae Proteins
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Serine Endopeptidases
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IgA-specific serine endopeptidase