Abstract
A non-nucleoside class of compounds that inhibits the replication of hepatitis B virus (HBV) in cell culture has been discovered. A series of substituted analogues of phenylpropenamide 6 has been prepared and evaluated in the HepAD38 cellular assay. Structure-activity relationships of this series are discussed.
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Benzamides / chemistry
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Benzamides / pharmacology*
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Cell Line
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Hepatitis B virus / drug effects*
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Hepatitis B virus / physiology
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Piperidines / chemistry
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Piperidines / pharmacology*
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Structure-Activity Relationship
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Virus Replication / drug effects*
Substances
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Antiviral Agents
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Benzamides
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Piperidines