Abstract
Microdilution MICs of levofloxacin against twelve anaerobes ranged between 0.5-8.0 microg/ml and those of clindamycin and metronidazole between 0.008-2.0 and 0.25->16.0 microg/ml, respectively. Combination of levofloxacin with clindamycin and/or metronidazole in time-kill tests led to synergy at levofloxacin concentrations at or below the MIC in 7/12 strains.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / pharmacology*
-
Bacteremia / microbiology
-
Bacteria, Anaerobic / drug effects*
-
Clindamycin / pharmacology*
-
Drug Combinations
-
Drug Synergism
-
Humans
-
Levofloxacin*
-
Metronidazole / pharmacology*
-
Microbial Sensitivity Tests / methods
-
Ofloxacin / pharmacology*
Substances
-
Anti-Bacterial Agents
-
Drug Combinations
-
Metronidazole
-
Clindamycin
-
Levofloxacin
-
Ofloxacin