Anti-anaerobic activity of levofloxacin alone and combined with clindamycin and metronidazole

Diagn Microbiol Infect Dis. 2000 Nov;38(3):181-3. doi: 10.1016/s0732-8893(00)00190-5.

Abstract

Microdilution MICs of levofloxacin against twelve anaerobes ranged between 0.5-8.0 microg/ml and those of clindamycin and metronidazole between 0.008-2.0 and 0.25->16.0 microg/ml, respectively. Combination of levofloxacin with clindamycin and/or metronidazole in time-kill tests led to synergy at levofloxacin concentrations at or below the MIC in 7/12 strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacteremia / microbiology
  • Bacteria, Anaerobic / drug effects*
  • Clindamycin / pharmacology*
  • Drug Combinations
  • Drug Synergism
  • Humans
  • Levofloxacin*
  • Metronidazole / pharmacology*
  • Microbial Sensitivity Tests / methods
  • Ofloxacin / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Drug Combinations
  • Metronidazole
  • Clindamycin
  • Levofloxacin
  • Ofloxacin