Abstract
The susceptibilities of 43 pharyngeal isolates of Capnocytophaga to beta-lactam antibiotics, alone or in combination with beta-lactamase inhibitors, were tested by an agar dilution method. The 34 beta-lactamase-positive strains were highly resistant to beta-lactams, but the intrinsic activities of clavulanate, tazobactam, and sulbactam against Capnocytophaga, even beta-lactamase producers, indicates that these beta-lactamase inhibitors could be used for empirical treatment of neutropenic patients with oral sources of infection.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Capnocytophaga / drug effects*
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Capnocytophaga / enzymology
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Clavulanic Acid / pharmacology
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Clavulanic Acid / therapeutic use
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Gram-Negative Bacterial Infections / microbiology
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Humans
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Microbial Sensitivity Tests
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Penicillanic Acid / analogs & derivatives*
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Penicillanic Acid / pharmacology
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Penicillanic Acid / therapeutic use
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Tazobactam
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beta-Lactam Resistance
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beta-Lactamase Inhibitors*
Substances
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Anti-Bacterial Agents
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beta-Lactamase Inhibitors
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Clavulanic Acid
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Penicillanic Acid
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Tazobactam