In-vitro synergistic activity of the combination of ampicillin and arbekacin against vancomycin-and high-level gentamicin-resistant Enterococcus faecium with the aph(2")-Id gene

V Kak; I You; M J Zervos; R Kariyama; H Kumon; J W Chow

doi:10.1016/s0732-8893(00)00155-3

In-vitro synergistic activity of the combination of ampicillin and arbekacin against vancomycin-and high-level gentamicin-resistant Enterococcus faecium with the aph(2")-Id gene

Diagn Microbiol Infect Dis. 2000 Aug;37(4):297-9. doi: 10.1016/s0732-8893(00)00155-3.

Authors

V Kak¹, I You, M J Zervos, R Kariyama, H Kumon, J W Chow

Affiliation

¹ Research and Medical Service, John D Dingell VA Medical Center, and Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA.

PMID: 10974585
DOI: 10.1016/s0732-8893(00)00155-3

Abstract

The combination of ampicillin plus arbekacin produced synergistic killing against 8 of 13 vancomycin-, ampicillin-, gentamicin-, and streptomycin-resistant Enterococcus faecium isolates that possess the high-level gentamicin resistance gene, aph(2")-Id. This combination may prove useful in treating infections caused by multiresistant enterococci.

MeSH terms

Aminoglycosides*
Ampicillin / pharmacology*
Anti-Bacterial Agents / pharmacology*
Bacterial Proteins*
DNA, Bacterial / analysis
Dibekacin / analogs & derivatives*
Dibekacin / pharmacology
Drug Resistance, Microbial
Drug Synergism
Drug Therapy, Combination / pharmacology*
Enterococcus faecium / drug effects*
Enterococcus faecium / genetics
Gentamicins / pharmacology
Humans
Microbial Sensitivity Tests
Phosphotransferases (Alcohol Group Acceptor) / genetics*
Polymerase Chain Reaction
Streptomycin / pharmacology
Vancomycin / pharmacology

Substances

Aminoglycosides
Anti-Bacterial Agents
Bacterial Proteins
DNA, Bacterial
Gentamicins
Dibekacin
Vancomycin
Ampicillin
APH(2'')-Id protein, Enterococcus
Phosphotransferases (Alcohol Group Acceptor)
arbekacin
Streptomycin