Abstract
Enterococcus faecalis LC40 is an ampicillin-susceptible clinical isolate with high-level gentamicin resistance due to the aac(6')-Ie-aph(2")-Ia aminoglycoside resistance gene. The combination of ampicillin plus arbekacin reduced mean bacterial vegetation counts significantly more than ampicillin alone or ampicillin plus gentamicin in a rabbit model of aortic-valve endocarditis caused by E. faecalis LC40.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aminoglycosides*
-
Ampicillin / therapeutic use*
-
Animals
-
Anti-Bacterial Agents / pharmacology
-
Anti-Bacterial Agents / therapeutic use*
-
Dibekacin / analogs & derivatives*
-
Dibekacin / therapeutic use*
-
Disease Models, Animal
-
Drug Resistance, Microbial / physiology
-
Drug Therapy, Combination / therapeutic use*
-
Endocarditis, Bacterial / drug therapy*
-
Endocarditis, Bacterial / microbiology
-
Enterococcus faecalis / drug effects
-
Gentamicins / pharmacology
-
Gram-Positive Bacterial Infections / drug therapy*
-
Gram-Positive Bacterial Infections / microbiology
-
Microbial Sensitivity Tests
-
Rabbits
-
Treatment Outcome
Substances
-
Aminoglycosides
-
Anti-Bacterial Agents
-
Gentamicins
-
Dibekacin
-
Ampicillin
-
arbekacin