Abstract
The in vitro activities of GAR-936, the 9-t-butylglycylamido derivative of minocycline, were compared with those of doxycycline, minocycline, and tetracycline against 527 gram-positive clinical isolates. GAR-936 inhibited all strains, including those resistant to other tetracyclines, at concentrations of </=2 microg/ml, except two strains of JK diphtheroids for which the MIC was 4 microg/ml.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Microbial / physiology
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Gram-Positive Bacteria / drug effects*
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Humans
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Microbial Sensitivity Tests
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Minocycline / analogs & derivatives*
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Minocycline / pharmacology*
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Tetracycline / pharmacology
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Tigecycline
Substances
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Anti-Bacterial Agents
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Tigecycline
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Tetracycline
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Minocycline