Abstract
A plasmid-encoded extended-spectrum TEM beta-lactamase with a pI of 5.5 was detected in a Capnocytophaga ochracea clinical isolate. The bla gene was associated with a strong TEM-2 promoter and was derived from bla(TEM-1a) with a single-amino-acid substitution: Glu(104)-->Lys, previously assigned to TEM-17, which is thus the first TEM beta-lactamase to be reported in the phylum Flavobacter-Bacteroides.
MeSH terms
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Amino Acid Substitution
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Anti-Bacterial Agents / pharmacology
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Capnocytophaga / drug effects
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Capnocytophaga / enzymology*
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Capnocytophaga / genetics*
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Gram-Negative Bacterial Infections / microbiology*
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Humans
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Isoelectric Point
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Plasmids / genetics*
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Sequence Analysis, DNA
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beta-Lactam Resistance
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beta-Lactamases / genetics*
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beta-Lactamases / isolation & purification
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beta-Lactamases / metabolism
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beta-Lactams
Substances
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Anti-Bacterial Agents
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beta-Lactams
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beta-Lactamases