Heterogeneous vancomycin resistance in methicillin-resistant Staphylococcus aureus strains isolated in a large Italian hospital

J Clin Microbiol. 2000 Feb;38(2):866-9. doi: 10.1128/JCM.38.2.866-869.2000.

Abstract

Of 179 methicillin-resistant Staphylococcus aureus strains isolated from 1997 to 1998, two strains (1.1%) gave subclones for which the vancomycin MICs were 8 mg/liter. Pulsed-field gel electrophoresis showed identical restriction patterns for both isolates, suggesting transfer of a single clone between two different patients.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Electrophoresis, Gel, Pulsed-Field
  • Hospitals, University
  • Humans
  • Italy / epidemiology
  • Male
  • Methicillin Resistance*
  • Middle Aged
  • Staphylococcal Infections / epidemiology*
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics*
  • Staphylococcus aureus / isolation & purification
  • Vancomycin / pharmacology
  • Vancomycin Resistance*

Substances

  • Anti-Bacterial Agents
  • Vancomycin