Abstract
Cryptosporidium parvum can be regarded as a minimally invasive mucosal pathogen, since it invades surface epithelial cells that line the intestinal tract but does not invade deeper layers of the intestinal mucosa. Nonetheless, infection can be associated with diarrhea and marked mucosal inflammation. This article briefly reviews in vitro and in vivo models useful for studying the pathogenesis of C. parvum infection and explores the role of innate and acquired immune responses in host defense against this protozoan parasite.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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AIDS-Related Opportunistic Infections / parasitology
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Animals
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Antibody Formation
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Cells, Cultured / parasitology
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Chemokine CXCL1
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Chemokines, CXC*
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Chemotactic Factors / analysis
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Cryptosporidiosis / immunology
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Cryptosporidiosis / parasitology*
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Cryptosporidiosis / pathology
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Cryptosporidium parvum / cytology
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Cryptosporidium parvum / pathogenicity*
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Disease Models, Animal
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Epithelial Cells / immunology
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Epithelial Cells / parasitology
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Epithelial Cells / pathology
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Growth Substances / analysis
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Humans
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Immunity, Cellular
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Immunity, Innate
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Intercellular Signaling Peptides and Proteins*
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Interferon-gamma / immunology
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Interleukin-8 / analysis
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Intestines / parasitology
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Intestines / pathology
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Up-Regulation
Substances
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CXCL1 protein, human
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Chemokine CXCL1
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Chemokines, CXC
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Chemotactic Factors
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Growth Substances
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Intercellular Signaling Peptides and Proteins
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Interleukin-8
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Interferon-gamma