Cytomegalovirus (CMV) DNA load is an independent predictor of CMV disease and survival in advanced AIDS

J Virol. 1999 Aug;73(8):7027-30. doi: 10.1128/JVI.73.8.7027-7030.1999.

Abstract

The impact of cytomegalovirus (CMV) on human immunodeficiency virus type 1 (HIV-1) disease progression has been controversial. In this study, we sought to determine if CMV viral load is independent of HIV-1 viral load in predicting CMV disease and survival. Our findings indicate that in patients with advanced AIDS, CMV DNA load is an independent marker of CMV disease and survival and is more predictive than HIV-1 RNA load. Moreover, patients who respond to preemptive therapy with oral ganciclovir, with resulting undetectable levels of CMV DNA, in their plasma, have a significantly lower risk of developing CMV disease and higher rates of survival, despite stable or increasing HIV-1 RNA loads. These data provide support for CMV as an independent risk factor for mortality in persons with advanced AIDS and further suggest that effective preemptive therapy for CMV can improve patient survival rates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS-Related Opportunistic Infections / blood
  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / physiopathology
  • AIDS-Related Opportunistic Infections / virology*
  • Adult
  • Antiviral Agents / therapeutic use
  • Cytomegalovirus / genetics*
  • Cytomegalovirus Infections / blood
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / physiopathology
  • Cytomegalovirus Infections / virology*
  • DNA, Viral / blood*
  • Female
  • Ganciclovir / therapeutic use
  • HIV-1 / genetics
  • Humans
  • Male
  • Predictive Value of Tests
  • RNA, Viral / blood
  • Survivors
  • Viral Load*

Substances

  • Antiviral Agents
  • DNA, Viral
  • RNA, Viral
  • Ganciclovir