In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

M Akova; D Gür; D M Livermore; T Kocagöz; H E Akalin

doi:10.1128/AAC.43.5.1298

In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

Antimicrob Agents Chemother. 1999 May;43(5):1298-300. doi: 10.1128/AAC.43.5.1298.

Authors

M Akova¹, D Gür, D M Livermore, T Kocagöz, H E Akalin

Affiliation

¹ Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, 06100 Ankara, Turkey.

Abstract

Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Azithromycin / pharmacology*
Brucella melitensis / drug effects*
Brucella melitensis / metabolism
Doxycycline / pharmacology*
Drug Therapy, Combination / pharmacology*
Hydrogen-Ion Concentration
Quinolones / pharmacology*
Rifampin / pharmacology*
Streptomycin / pharmacology*

Substances

Quinolones
Azithromycin
Doxycycline
Rifampin
Streptomycin