Bacteriostatic and bactericidal in vitro activities of clarithromycin and erythromycin against periodontopathic Actinobacillus actinomycetemcomitans

Antimicrob Agents Chemother. 1998 Nov;42(11):3000-1. doi: 10.1128/AAC.42.11.3000.

Abstract

The susceptibilities of 87 periodontitis-associated strains of Actinobacillus actinomycetemcomitans to clarithromycin and erythromycin were determined by standard methodology recommended for Haemophilus influenzae. For clarithromycin the MIC at which 90% of the isolates were inhibited was </=2.0 microg/ml and the minimal bactericidal concentration at which 90% of the strains were killed was </=4.0 microg/ml, suggesting that it would be a candidate for therapeutic trials in patients with periodontitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggregatibacter actinomycetemcomitans / drug effects*
  • Anti-Bacterial Agents / pharmacology*
  • Clarithromycin / pharmacology*
  • Erythromycin / pharmacology*
  • Microbial Sensitivity Tests
  • Periodontitis / drug therapy*
  • Periodontitis / microbiology

Substances

  • Anti-Bacterial Agents
  • Erythromycin
  • Clarithromycin