Susceptibilities of Legionella spp. to newer antimicrobials in vitro

Antimicrob Agents Chemother. 1998 Jun;42(6):1520-3. doi: 10.1128/AAC.42.6.1520.

Abstract

The in vitro activities of 13 antimicrobial agents against 30 strains of Legionella spp. were determined. Rifapentine, rifampin, and clarithromycin were the most potent agents (MICs at which 90% of isolates are inhibited [MIC90s], < or = 0.008 microgram/ml). The ketolide HMR 3647 and the fluoroquinolones levofloxacin and BAY 12-8039 (MIC90s, 0.03 to 0.06 microgram/ml) were more active than erythromycin A or roxithromycin. The MIC90s of dalfopristin-quinupristin and linezolid were 0.5 and 8 micrograms/ml, respectively. Based on class characteristics and in vitro activities, several of these agents may have potential roles in the treatment of Legionella infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Aza Compounds*
  • Fluoroquinolones*
  • Humans
  • Ketolides*
  • Legionella / drug effects*
  • Macrolides*
  • Microbial Sensitivity Tests
  • Moxifloxacin
  • Quinolines*
  • Quinolones / pharmacology
  • Rifampin / analogs & derivatives
  • Rifampin / pharmacology

Substances

  • Anti-Bacterial Agents
  • Aza Compounds
  • Fluoroquinolones
  • Ketolides
  • Macrolides
  • Quinolines
  • Quinolones
  • telithromycin
  • Moxifloxacin
  • Rifampin
  • rifapentine