In vitro and in vivo antichlamydial activities of HSR-903, a new fluoroquinolone antibiotic

Y Niki; N Miyashita; Y Kubota; M Nakajima; T Matsushima

doi:10.1128/AAC.41.4.857

In vitro and in vivo antichlamydial activities of HSR-903, a new fluoroquinolone antibiotic

Antimicrob Agents Chemother. 1997 Apr;41(4):857-9. doi: 10.1128/AAC.41.4.857.

Authors

Y Niki¹, N Miyashita, Y Kubota, M Nakajima, T Matsushima

Affiliation

¹ Department of Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Japan.

Abstract

The in vitro and in vivo antichlamydial activities of HSR-903 were investigated. The MICs of HSR-903 for different species of chlamydia were 0.016 to 0.063 microg/ml, which were superior to those of conventional fluoroquinolones. The therapeutic effect of HSR-903 in experimental mouse Chlamydia psittaci pneumonia was also excellent and almost equal to that of minocycline and superior to that of ofloxacin. These results indicate that HSR-903 may be useful in the treatment of respiratory infections caused by chlamydiae.

Publication types

Comparative Study

MeSH terms

Animals
Anti-Bacterial Agents / therapeutic use
Anti-Infective Agents / pharmacology*
Anti-Infective Agents / therapeutic use*
Chlamydia / drug effects*
Chlamydophila psittaci / drug effects*
Fluoroquinolones*
HeLa Cells
Humans
Male
Mice
Mice, Inbred ICR
Microbial Sensitivity Tests
Minocycline / therapeutic use
Ofloxacin / therapeutic use
Psittacosis / drug therapy*
Psittacosis / microbiology
Quinolones / pharmacology*
Quinolones / therapeutic use

Substances

Anti-Bacterial Agents
Anti-Infective Agents
Fluoroquinolones
Quinolones
Ofloxacin
Minocycline
olamufloxacin