Incidence of acute oligoanuric renal failure in dextran 40 treated patients with acute ischemic stroke stage III or IV

Ren Fail. 1997 Jan;19(1):69-75. doi: 10.3109/08860229709026261.

Abstract

Two hundred eleven patients with acute ischemic stroke, stage III or IV, received daily intravenous infusion of 500-1000 mL low-molecular dextran (dextran 40) over a period of 4 days. In 10 cases (4.7%) acute renal failure, associated with dextran infusion, could be observed; oligoanuria occurred after a mean time of 4 (3-6) days. The incidence of dextran-induced acute renal failure was significantly higher in patients with a preexisting reduction of glomerular filtration rate below 30 mL/min/1.73 m2 (p < 0.005). Five of the patients (50%) with acute renal failure died within 4-12 days after the hemodilution therapy with dextran 40; this high lethality was due to nonrenal complications.

MeSH terms

  • Acute Disease
  • Acute Kidney Injury / chemically induced*
  • Acute Kidney Injury / physiopathology
  • Adult
  • Aged
  • Aged, 80 and over
  • Anticoagulants / administration & dosage
  • Anticoagulants / adverse effects*
  • Anticoagulants / therapeutic use
  • Anuria / chemically induced*
  • Anuria / physiopathology
  • Brain Ischemia / complications
  • Brain Ischemia / diagnostic imaging
  • Brain Ischemia / drug therapy*
  • Dextrans / administration & dosage
  • Dextrans / adverse effects*
  • Dextrans / therapeutic use
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Humans
  • Incidence
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Radiography
  • Renal Replacement Therapy
  • Retrospective Studies

Substances

  • Anticoagulants
  • Dextrans