Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: evaluation of current treatment

Antimicrob Agents Chemother. 1995 Oct;39(10):2356-8. doi: 10.1128/AAC.39.10.2356.

Abstract

The postantibiotic effects (PAEs) OF 16 antibiotics or antibiotic combinations currently used against Burkholderia (Pseudomonas) pseudomallei were determined. The beta-lactams had zero PAEs, while the carbapenems and ciprofloxacin induced median PAEs of 1 and 5 h, respectively. These results emphasize the need to maintain antibiotic levels above inhibitory concentrations in blood throughout the dosing interval in cases of severe melioidosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Burkholderia pseudomallei / drug effects*
  • Drug Therapy, Combination / pharmacology
  • Humans
  • Melioidosis / drug therapy*

Substances

  • Anti-Bacterial Agents