Persistent catheter-related bacteremia: clearance with antibiotics and urokinase

J Pediatr Surg. 1993 Apr;28(4):627-9. doi: 10.1016/0022-3468(93)90675-b.

Abstract

A patient with terminal osteogenic sarcoma and catheter-related coagulase-negative staphylococcal bacteremia was treated with vancomycin and blood cultures were positive for 4 days documented with quantitative colony counts. Urokinase therapy was initiated and was associated with a transient bacteremia with markedly increased colony counts of coagulase-negative Staphylococcus prior to eradication of the catheter-related infection. We feel that the combination of urokinase and appropriate antibiotics may be an effective method to eradicate line-associated coagulase-negative staphylococcal infection in selected patients.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / administration & dosage*
  • Bacteremia / drug therapy*
  • Bacteremia / etiology*
  • Catheterization, Central Venous / adverse effects*
  • Female
  • Humans
  • Osteosarcoma / drug therapy
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / etiology
  • Urokinase-Type Plasminogen Activator / administration & dosage*

Substances

  • Anti-Bacterial Agents
  • Urokinase-Type Plasminogen Activator