In vitro susceptibility of quinolone-resistant Campylobacter jejuni to new macrolide antibiotics

Eur J Clin Microbiol Infect Dis. 1993 Jan;12(1):48-50. doi: 10.1007/BF01997058.

Abstract

The MICs of erythromycin and three new macrolide antibiotics were determined for 36 quinolone-susceptible and 106 quinolone-resistant Campylobacter jejuni. The MIC90 values of azithromycin, clarithromycin, roxithromycin and erythromycin were 0.5, 4, 16 and 4 mg/l respectively. No difference was found between macrolide activity against the quinolone-susceptible and the quinolone-resistant strains. Clarithromycin and especially azithromycin might eventually replace erythromycin for the treatment of Campylobacter jejuni infections in view of their pharmacological properties.

MeSH terms

  • 4-Quinolones
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Infective Agents / pharmacology*
  • Campylobacter jejuni / drug effects*
  • Drug Resistance, Microbial
  • Macrolides
  • Microbial Sensitivity Tests

Substances

  • 4-Quinolones
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Macrolides