Candida prosthetic arthritis: report of a case treated with fluconazole and review of the literature

Am J Med. 1993 Jan;94(1):100-3. doi: 10.1016/0002-9343(93)90127-b.

Abstract

Prosthetic arthritis due to Candida species is uncommon, with only 15 cases reported in the literature. We recently cared for a human immunodeficiency virus-infected patient who developed Candida parapsilosis prosthetic arthritis unresponsive to resection arthroplasty, intravenous amphotericin B, and suppressive ketoconazole therapy. Treatment with fluconazole led to mycologic cure and symptom improvement, although he subsequently underwent above-the-knee amputation due to continued joint instability. Fluconazole may be useful follow-up therapy after a course of amphotericin B combined with resection arthroplasty or when removal of the prosthesis cannot be accomplished.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Arthritis, Infectious / drug therapy*
  • Arthritis, Infectious / etiology
  • Candidiasis / drug therapy*
  • Candidiasis / etiology
  • Fluconazole / therapeutic use*
  • HIV Infections / complications
  • HIV Infections / etiology
  • Humans
  • Knee Prosthesis / adverse effects*
  • Male
  • Prosthesis-Related Infections / drug therapy*

Substances

  • Fluconazole