The antimicrobial activity and beta-lactamase stability of cefpirome, a new fourth-generation cephalosporin in comparison with other agents

J Antimicrob Chemother. 1993 May;31(5):699-709. doi: 10.1093/jac/31.5.699.

Abstract

The antimicrobial activity of cefpirome was compared with amoxycillin/clavulanic acid, ampicillin/sulbactam, cefuroxime, ceftazidime, gentamicin and amikacin against 743 non-duplicate clinical isolates. MIC50 and MIC90 showed that the antibiotic was active against both Gram-negative and Gram-positive organisms. Cefpirome was highly active against most of the Enterobacteriaceae, including indole-positive Proteus spp., Aeromonas spp. (MIC < or = 1 mg/L) and Salmonella spp. (MIC < or = 0.5 mg/L). Neisseria gonorrhoeae and Haemophilus influenzae (including beta-lactamase producers) were all susceptible, with MIC less than 0.5 and 0.25 mg/L respectively. Cefpirome was more active than cefuroxime and ceftazidime against Campylobacter spp. (MIC < or = 2 mg/L), but less active than ceftazidime against Pseudomonas aeruginosa. Cefpirome was active against Streptococcus pneumoniae. Streptococcus bovis and coagulase-negative staphylococci (MIC < or = 0.5 mg/L) and methicillin-sensitive Staphylococcus aureus (MIC < or = 2 mg/L). Methicillin-resistant S. aureus, Gram-positive and Gram-negative anaerobes were resistant to cefpirome. The stability of cefpirome to TEM-1, TEM-2, PSE-1, SHV-1 and the chromosomal-mediated P99 and K-1 beta-lactamases was comparable to ceftazidime.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter / drug effects
  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects*
  • Bacteria / genetics
  • Bacteria, Anaerobic / drug effects
  • Bacterial Infections / microbiology
  • Cefpirome
  • Cephalosporins / metabolism
  • Cephalosporins / pharmacology*
  • Citrobacter / drug effects
  • Enterobacter / drug effects
  • Gram-Negative Aerobic Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Staphylococcus aureus / drug effects
  • Xanthomonas / drug effects
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • beta-Lactamases