Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin

Antimicrob Agents Chemother. 1993 Nov;37(11):2493-5. doi: 10.1128/AAC.37.11.2493.

Abstract

All 47 sequential blood culture isolates of viridans group streptococci obtained from febrile neutropenic patients receiving quinolone prophylaxis were susceptible to vancomycin, teicoplanin, and imipenem. Resistance to benzylpenicillin (MIC for 50% of isolates [MIC50], 0.125 microgram/ml) and ceftazidime (MIC50, 4 micrograms/ml) was common. Most isolates were susceptible to amoxicillin, co-amoxiclav (amoxicillin-clavulanic acid at a 2:1 ratio by weight), azlocillin, clarithromycin, and erythromycin, with azithromycin showing comparable activity. The MIC90 of sparfloxacin was 1 microgram/ml; those for ciprofloxacin and ofloxacin were > 16 and 16 micrograms/ml, respectively.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Ciprofloxacin / therapeutic use*
  • Drug Resistance, Microbial
  • Drug Synergism
  • Humans
  • Microbial Sensitivity Tests
  • Neutropenia / blood
  • Neutropenia / complications*
  • Streptococcal Infections / blood
  • Streptococcal Infections / drug therapy
  • Streptococcal Infections / microbiology*
  • Streptococcus / drug effects*

Substances

  • Anti-Bacterial Agents
  • Ciprofloxacin