Multicenter comparison of in vitro activities of FK-037, cefepime, ceftriaxone, ceftazidime, and cefuroxime

Antimicrob Agents Chemother. 1993 Aug;37(8):1696-700. doi: 10.1128/AAC.37.8.1696.

Abstract

In a multicenter study, the MICs of FK-037 for 90% of the strains tested (MIC90s) were < or = 1 microgram/ml for members of the family Enterobacteriaceae other than Citrobacter freundii, Enterobacter spp., and Serratia marcescens. Activity against Pseudomonas aeruginosa was variable, with a MIC50 and a MIC90 of 4 and 32 micrograms/ml, respectively. Relative to cefepime, however, FK-037 was less active against ceftazidime-resistant isolates of Enterobacter cloacae. The MIC90 of FK-037 for methicillin-resistant staphylococci was > 16 micrograms/ml.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cefepime
  • Ceftazidime / pharmacology
  • Ceftizoxime / analogs & derivatives
  • Ceftizoxime / pharmacology
  • Ceftriaxone / pharmacology
  • Cefuroxime / pharmacology
  • Cephalosporins / pharmacology*
  • Gram-Negative Bacteria / drug effects*
  • Gram-Positive Bacteria / drug effects*
  • Humans
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • cefoselis
  • Ceftriaxone
  • Cefepime
  • Ceftazidime
  • Ceftizoxime
  • Cefuroxime