Abstract
In a multicenter study, the MICs of FK-037 for 90% of the strains tested (MIC90s) were < or = 1 microgram/ml for members of the family Enterobacteriaceae other than Citrobacter freundii, Enterobacter spp., and Serratia marcescens. Activity against Pseudomonas aeruginosa was variable, with a MIC50 and a MIC90 of 4 and 32 micrograms/ml, respectively. Relative to cefepime, however, FK-037 was less active against ceftazidime-resistant isolates of Enterobacter cloacae. The MIC90 of FK-037 for methicillin-resistant staphylococci was > 16 micrograms/ml.
Publication types
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Comparative Study
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Cefepime
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Ceftazidime / pharmacology
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Ceftizoxime / analogs & derivatives
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Ceftizoxime / pharmacology
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Ceftriaxone / pharmacology
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Cefuroxime / pharmacology
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Cephalosporins / pharmacology*
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Gram-Negative Bacteria / drug effects*
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Gram-Positive Bacteria / drug effects*
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Humans
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Microbial Sensitivity Tests
Substances
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Anti-Bacterial Agents
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Cephalosporins
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cefoselis
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Ceftriaxone
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Cefepime
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Ceftazidime
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Ceftizoxime
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Cefuroxime