Abstract
Objective:
The arthritogenic potential of the cationic outer surface proteins (Osp) from Borrelia burgdorferi was tested in rats.
Methods:
Water-soluble Osps were prepared by butanol extraction and were administered by intraarticular injection. Tissue injury was assessed by scintigraphy and histology.
Results:
A mild arthritis was seen in naive rats. Preimmunized animals had more severe, longer lasting bouts of inflammation.
Conclusion:
The Osps of Borrelia burgdorferi are potent arthritogens in rats. These immunodominant antigens may play a role in the development of Lyme arthritis in humans.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens, Bacterial / immunology
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Arthritis, Infectious / etiology*
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Arthritis, Infectious / immunology*
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Arthritis, Infectious / microbiology
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Bacterial Outer Membrane Proteins / pharmacology*
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Borrelia burgdorferi Group* / chemistry
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Inflammation / diagnostic imaging
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Lyme Disease*
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Male
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Radionuclide Imaging
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Rats
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Rats, Wistar
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Recombinant Proteins / pharmacology
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Synovial Fluid / chemistry
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Technetium
Substances
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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Recombinant Proteins
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Technetium