In-vitro activity of clinafloxacin (CI-960) and PD 131628-2 against anaerobic bacteria

J Antimicrob Chemother. 1994 Oct;34(4):579-84. doi: 10.1093/jac/34.4.579.

Abstract

The antimicrobial activities of two new quinolones, CI-960 and PD 131628-2 were determined against 339 strains of anaerobic bacteria and compared to cefoxitin, imipenem and metronidazole. The NCCLS-approved Wadsworth agar dilution technique with Brucella-lysed blood agar was used throughout the study. Breakpoints of the new quinolones are 2 mg/L, and breakpoints for cefoxitin, imipenem and metronidazole are 32, 8 and 16 mg/L, respectively. CI-960 displayed excellent activity, inhibiting all strains tested at 1 mg/L. PD 131628-2 inhibited 94% of Bacteroides fragilis, 75% of other B. fragilis group isolates, 87% of Prevotella spp, 79% of the Fusobacterium mortiferum-varium group, 74% of non-sporing gram-positive bacilli, and 89-100% of Clostridium spp other than Clostridium difficile at 2 mg/L. None of the eight strains of C. difficile was inhibited at 2 mg/L although they were inhibited at 4 mg/L. PD 131628-2 inhibited all strains of other Bacteroides spp, Porphyromonas spp, and Fusobacterium nucleatum at < or = 1 mg/L.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Bacteria, Anaerobic / drug effects*
  • Bacterial Infections / microbiology
  • Culture Media
  • Fluoroquinolones*
  • Humans
  • Microbial Sensitivity Tests
  • Naphthyridines / pharmacology*
  • Quinolones / pharmacology*

Substances

  • Anti-Infective Agents
  • Culture Media
  • Fluoroquinolones
  • Naphthyridines
  • Quinolones
  • PD 131628
  • clinafloxacin