Candidal brain abscess associated with vascular invasion: a devastating complication of vascular catheter-related candidemia

Clin Infect Dis. 1995 Jul;21(1):202-5. doi: 10.1093/clinids/21.1.202.

Abstract

We describe a patient who developed Candida albicans brain abscess associated with prominent vascular invasion following an episode of central venous catheter-related fungemia. The increasing population of immunosuppressed patients and the frequent use of broad-spectrum antimicrobials, corticosteroids, chemotherapeutics, organ transplantation, and prolonged supportive measures are responsible for an increasing incidence of candidal infections. Brain abscess is a rare complication of candidemia but may be expected to become more common as venous catheter-related fungemia is encountered more frequently.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / therapeutic use
  • Arterial Occlusive Diseases / diagnosis
  • Arterial Occlusive Diseases / etiology
  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain Abscess / diagnosis
  • Brain Abscess / drug therapy
  • Brain Abscess / microbiology*
  • Candida albicans / isolation & purification
  • Candidiasis / diagnosis
  • Candidiasis / drug therapy
  • Candidiasis / etiology*
  • Carotid Artery Diseases / diagnosis
  • Carotid Artery Diseases / etiology
  • Carotid Artery, Internal / pathology
  • Catheterization, Central Venous / adverse effects*
  • Cerebral Arteries / pathology
  • Craniotomy
  • Drug Therapy, Combination
  • Flucytosine / therapeutic use
  • Fungemia / diagnosis
  • Fungemia / drug therapy
  • Fungemia / etiology*
  • Humans
  • Magnetic Resonance Angiography
  • Male
  • Middle Aged
  • Tomography, X-Ray Computed

Substances

  • Amphotericin B
  • Flucytosine