Five patients with mucormycosis of the heart are described. Two had leukemia,, one had multiple myeloma, one sideroblastic anemia, and one had been wounded when a body trap exploded. None had diabetes. In addition to heart involvement, each had mucormycosis of the lungs. Kidney was infected in two patients and gastrointestinal tract, spleen, liver, adrenal, brain, and skin were each involved in one patient. Three patients had cardiac symptoms. The findings in ten previously reported patients with de novo cardiac mucormycosis and in four patients with mucormycosis occurring in association with cardiovascular surgery are summarized.