Intrahepatic cholestasis and sicca complex after thiabendazole. Report of a case and review of the literature

Gastroenterology. 1983 Sep;85(3):718-21.

Abstract

Thiabendazole is a relatively safe and effective agent with a wide range of activity against nematodes infesting the gastrointestinal tract. A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy. Endoscopic retrograde cholangiopancreatography demonstrated normal biliary tree and pancreatic ducts. Liver biopsy was consistent with a drug-induced intrahepatic cholestatic reaction. The patient recovered completely from his liver injury, but the sicca complex persisted 1 yr after the drug was given. The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Cholangiopancreatography, Endoscopic Retrograde
  • Cholestasis, Intrahepatic / chemically induced*
  • Cholestasis, Intrahepatic / diagnostic imaging
  • Humans
  • Liver / pathology
  • Male
  • Middle Aged
  • Sjogren's Syndrome / chemically induced*
  • Strongyloidiasis / drug therapy
  • Thiabendazole / adverse effects*
  • Thiabendazole / therapeutic use
  • Time Factors

Substances

  • Thiabendazole