Synergy of combinations of vancomycin, gentamicin, and rifampin against methicillin-resistant, coagulase-negative staphylococci

Antimicrob Agents Chemother. 1983 Jun;23(6):932-4. doi: 10.1128/AAC.23.6.932.

Abstract

The activity of combinations of vancomycin (2 or 10 micrograms/ml), gentamicin (0.3 micrograms/ml), and rifampin (0.03 micrograms/ml) against methicillin-resistant, coagulase-negative staphylococcal isolates was determined by the time-kill method. Combinations of rifampin with gentamicin or with vancomycin 2 micrograms/ml demonstrated enhanced killing against 13 of 17 and 13 of 25 strains, respectively. However, rifampin-resistant strains were selected with the latter combination in the remaining 12 of 25 studies.

MeSH terms

  • Coagulase / analysis*
  • Drug Combinations
  • Drug Synergism
  • Gentamicins / pharmacology*
  • Methicillin / pharmacology*
  • Microbial Sensitivity Tests
  • Penicillin Resistance
  • Rifampin / pharmacology*
  • Staphylococcus / drug effects*
  • Vancomycin / pharmacology*

Substances

  • Coagulase
  • Drug Combinations
  • Gentamicins
  • Vancomycin
  • Methicillin
  • Rifampin