Therapeutic activity of ceftazidime and eleven other beta-lactam antibiotics against experimental Haemophilus influenzae, type b meningitis

J Antimicrob Chemother. 1984 May;13(5):517-20. doi: 10.1093/jac/13.5.517.

Abstract

Twelve beta-lactams (11 cephalosporins and aztreonam) were compared in an infant rat model of Haemophilus influenzae, type b meningitis. Ceftazidime was the most effective compound tested and showed greater activity than cefuroxime, latamoxef (moxalactam) and cefotaxime--all of which have been used successfully in clinical haemophilus meningitis in children.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Aztreonam
  • Ceftazidime
  • Cephalosporins / therapeutic use*
  • Haemophilus influenzae
  • Meningitis, Haemophilus / drug therapy*
  • Rats

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Ceftazidime
  • Aztreonam