Cephalexin for the oral treatment of CAPD peritonitis

J Antimicrob Chemother. 1984 Feb;13(2):153-9. doi: 10.1093/jac/13.2.153.

Abstract

Sixteen episodes of peritonitis in 13 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) were treated with oral cephalexin given at each 6-hourly dialysate exchange. Serial measurements of the antibiotic concentration in serum and dialysate were made in seven cases. Cephalexin levels increased rapidly and by 12 h exceeded 27 mg/l in serum and 20 mg/l in dialysate. Dialysate levels considerably exceeded the minimum bactericidal concentration for organisms considered cephalexin-sensitive and in patients with these the clinical response was usually good. Although dialysate concentrations sometimes reached the minimum inhibitory concentration for organisms considered cephalexin-resistant the clinical response in patients from whom resistant bacteria were cultured was unsatisfactory. Intra-peritoneal antibiotic administration would seem unnecessary in many CAPD patients with peritonitis.

MeSH terms

  • Administration, Oral
  • Cephalexin / therapeutic use*
  • Escherichia coli Infections / drug therapy
  • Humans
  • Peritoneal Dialysis / adverse effects*
  • Peritoneal Dialysis, Continuous Ambulatory / adverse effects*
  • Peritonitis / drug therapy*
  • Peritonitis / etiology
  • Staphylococcal Infections / drug therapy
  • Streptococcal Infections / drug therapy

Substances

  • Cephalexin