Abstract
The mechanism of high-level resistance to streptomycin was studied in 12 clinical isolates of Streptococcus faecalis. Six strains produced streptomycin-modifying enzymes. Each of three enzyme-negative strains tested demonstrated ribosomal resistance to streptomycin. Lack of ribosomal susceptibility is a significant cause of high-level streptomycin resistance among clinical enterococcal isolates.
MeSH terms
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Drug Resistance, Microbial
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Enterococcus faecalis / drug effects*
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Enterococcus faecalis / enzymology
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Humans
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Kanamycin / pharmacology
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Nucleotidyltransferases / metabolism
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Phenylalanine / metabolism
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Ribosomes / drug effects*
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Streptococcal Infections / microbiology
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Streptomycin / pharmacology*
Substances
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Phenylalanine
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Kanamycin
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Nucleotidyltransferases
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streptomycin 3''-adenylyltransferase
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Streptomycin