Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine

G M Sheldrick; P G Jones; O Kennard; D H Williams; G A Smith

doi:10.1038/271223a0

Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine

Nature. 1978 Jan 19;271(5642):223-5. doi: 10.1038/271223a0.

Authors

G M Sheldrick, P G Jones, O Kennard, D H Williams, G A Smith

PMID: 622161
DOI: 10.1038/271223a0

Abstract

Vancomycin, a broad-spectrum antibiotic, inhibits the growth of cell walls by complex formation with peptides terminating in D-alanyl-D-alanine. The structure of vancomycin was determined by X-ray analysis of the degradation product CDP-I. A model of the complex is proposed based on this study and spectroscopic data.

MeSH terms

Dipeptides*
Models, Molecular
Molecular Conformation
Vancomycin* / analogs & derivatives
X-Ray Diffraction

Substances

Dipeptides
Vancomycin