Between March and November 1985 we treated 89 female patients with condyloma acuminatum of the lower genital tract. All patients were evaluated with colposcopy, urethroscopy and anoscopy. Carbon dioxide laser vaporization was used to treat condylomata in the cervix, vagina, vulva, anus and distal urethra. Urethral involvement by condylomata was found in 31 patients (35 per cent). Eight patients had biopsy proved proximal urethral condylomata (9 per cent). Cryotherapy was used to treat these lesions. Six patients required only 1 treatment, while 2 required 2 treatments to cure the proximal urethral condylomata.