Vancomycin pharmacokinetics and dose recommendations for preterm infants

Antimicrob Agents Chemother. 1987 Jan;31(1):52-4. doi: 10.1128/AAC.31.1.52.

Abstract

The pharmacokinetics of intravenous vancomycin was studied in 20 preterm infants (gestational age, 26.5 weeks +/- 2.6 weeks [standard deviation]; birthweight, 880 +/- 340 g). At the time of the studies their postconceptional age was 36.4 +/- 4.5 weeks. The drug was infused over 30 min in a dose between 9.2 and 18 mg/kg. A highly significant correlation existed between postconceptional age or body weight and vancomycin t1/2 and clearance. Serum creatinine concentrations correlated with vancomycin t1/2 and clearance. Serum creatinine tended to decrease with increasing postconceptional age. Based on the excellent correlation between age (or weight) and vancomycin pharmacokinetics, dose and dose-interval recommendations are presented.

MeSH terms

  • Drug Administration Schedule
  • Humans
  • Infant, Newborn
  • Infant, Premature / metabolism*
  • Infusions, Intravenous
  • Kinetics
  • Vancomycin / administration & dosage
  • Vancomycin / metabolism*

Substances

  • Vancomycin