Rhinocerebral mucormycosis with cerebral extension successfully treated with adjunctive hyperbaric oxygen therapy

Arch Otolaryngol Head Neck Surg. 1988 Jul;114(7):791-4. doi: 10.1001/archotol.1988.01860190095032.

Abstract

Rhinocerebral mucormycosis is a devastating fungal disease with a high mortality rate. Extensive surgical débridement and amphotericin B are currently the mainstays of therapy. When cerebral extension of the fungus occurs, the disease is almost invariably fatal. Two patients with rhinocerebral mucormycosis had progression of their infection to brain abscesses despite aggressive débridement surgery and amphotericin B therapy. Both patients showed marked clinical improvement with the addition of adjunctive hyperbaric oxygen therapy. Both patients remained free of their disease 21 months after hospital discharge.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amphotericin B / therapeutic use
  • Brain Abscess / diagnostic imaging
  • Brain Abscess / etiology
  • Brain Abscess / therapy*
  • Brain Diseases / complications
  • Brain Diseases / diagnostic imaging
  • Brain Diseases / therapy*
  • Combined Modality Therapy
  • Debridement
  • Female
  • Humans
  • Hyperbaric Oxygenation*
  • Ketoconazole / therapeutic use
  • Middle Aged
  • Mucormycosis / complications
  • Mucormycosis / diagnostic imaging
  • Mucormycosis / therapy*
  • Nose Diseases / complications
  • Nose Diseases / diagnostic imaging
  • Nose Diseases / therapy*
  • Prognosis
  • Time Factors
  • Tomography, X-Ray Computed

Substances

  • Amphotericin B
  • Ketoconazole