Comparative in vitro activity of PD 127,391, a new fluorinated 4-quinolone derivative

Antimicrob Agents Chemother. 1988 Aug;32(8):1278-81. doi: 10.1128/AAC.32.8.1278.

Abstract

PD 127,391, a newly developed 4-quinolone chemically similar to ciprofloxacin, was studied in vitro by using agar and broth dilution and two inoculum sizes. PD 127,391 was found to be highly active against gram-negative aerobes, including Pseudomonas aeruginosa and other Pseudomonas spp. Its activity against gram-positive aerobes was better than that of ciprofloxacin.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Bacteria, Aerobic / drug effects*
  • Ceftazidime / pharmacology
  • Chemical Phenomena
  • Chemistry
  • Ciprofloxacin / pharmacology
  • Fluoroquinolones*
  • Gentamicins / pharmacology
  • Gram-Negative Aerobic Bacteria / drug effects
  • Humans
  • Imipenem / pharmacology
  • Microbial Sensitivity Tests
  • Pseudomonas aeruginosa / drug effects

Substances

  • Anti-Infective Agents
  • Fluoroquinolones
  • Gentamicins
  • Ciprofloxacin
  • Imipenem
  • clinafloxacin
  • Ceftazidime