Abstract
We investigated the activity of roxithromycin (RU 965) and gamma interferon alone and in combination in a murine model of toxoplasmic encephalitis. Roxithromycin at a dosage of 35 or 50 mg per mouse per day decreased mortality. Gamma interferon alone significantly prolonged time to death. When combined, the two agents were remarkably synergistic.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animal Feed
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Animals
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Anti-Bacterial Agents / therapeutic use*
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Drug Synergism
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Drug Therapy, Combination
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Encephalitis / drug therapy*
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Female
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Interferon-gamma / therapeutic use*
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Leucomycins / therapeutic use*
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Mice
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Toxoplasmosis, Animal / drug therapy*
Substances
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Anti-Bacterial Agents
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Leucomycins
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Interferon-gamma