Abstract
An isolate of Candida albicans from a patient with chronic mucocutaneous candidosis who relapsed during ketoconazole treatment was compared with a number of other azole-sensitive and azole-resistant isolates by tests in vitro and in three animal models of vaginal or disseminated infection. In-vitro tests indicated that the isolate was cross-resistant to all imidazole and triazole antifungals tested. In the animal models, treatment with miconazole, ketoconazole, itraconazole or fluconazole failed to influence the infection.
Publication types
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Case Reports
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Comparative Study
MeSH terms
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Adult
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Animals
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Antifungal Agents / pharmacology*
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Antifungal Agents / therapeutic use
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Candida albicans / drug effects*
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Candidiasis / drug therapy*
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Candidiasis / microbiology
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Candidiasis, Chronic Mucocutaneous / drug therapy*
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Candidiasis, Chronic Mucocutaneous / microbiology
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Disease Models, Animal
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Drug Resistance, Microbial
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Econazole / pharmacology
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Econazole / therapeutic use
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Female
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Fluconazole
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Guinea Pigs
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Humans
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Imidazoles / pharmacology*
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Imidazoles / therapeutic use
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Itraconazole
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Ketoconazole / analogs & derivatives
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Ketoconazole / pharmacology
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Ketoconazole / therapeutic use
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Male
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Mice
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Miconazole / pharmacology
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Miconazole / therapeutic use
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Rats
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Rats, Inbred Strains
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Triazoles / pharmacology*
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Triazoles / therapeutic use
Substances
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Antifungal Agents
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Imidazoles
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Triazoles
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terconazole
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Itraconazole
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Econazole
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Miconazole
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Fluconazole
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Ketoconazole