Variability of IncHI1 plasmids from Salmonella typhi with special reference to Peruvian plasmids encoding resistance to trimethoprim and other antibiotics

D E Taylor; J C Chumpitaz; F Goldstein

doi:10.1128/AAC.28.3.452

Variability of IncHI1 plasmids from Salmonella typhi with special reference to Peruvian plasmids encoding resistance to trimethoprim and other antibiotics

Antimicrob Agents Chemother. 1985 Sep;28(3):452-5. doi: 10.1128/AAC.28.3.452.

Authors

D E Taylor, J C Chumpitaz, F Goldstein

Abstract

In spite of extensive DNA homology among IncHI1 plasmids, ApaI and XbaI restriction digests of plasmids from Peruvian Salmonella typhi varied considerably from other IncHI1 plasmids isolated previously. IncHI1 plasmids appear to be undergoing a process of modular evolution, probably by sequential acquisition of resistance determinants.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chloramphenicol / pharmacology
DNA Restriction Enzymes
DNA, Bacterial / genetics*
Drug Resistance, Microbial*
Penicillin Resistance
Peru
Plasmids*
Salmonella typhi / drug effects
Salmonella typhi / genetics*
Sequence Homology, Nucleic Acid
Trimethoprim / pharmacology*

Substances

DNA, Bacterial
Chloramphenicol
Trimethoprim
DNA Restriction Enzymes