Treatment of late Lyme borreliosis--randomised comparison of ceftriaxone and penicillin

Lancet. 1988 May 28;1(8596):1191-4. doi: 10.1016/s0140-6736(88)92011-9.

Abstract

23 patients with clinically active late Lyme disease were randomly assigned to intravenous treatment with either penicillin or ceftriaxone. Of the 10 treated with penicillin, 5 were judged treatment failures; of the 13 who received ceftriaxone, only 1 did not respond. An additional 31 patients were subsequently treated with ceftriaxone 4 g/day (n = 17) or 2 g/day (n = 14); success rates in both groups were comparable to those in the cohort randomised to ceftriaxone. Patients unresponsive to ceftriaxone were more likely to have received corticosteroid treatment.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adrenal Cortex Hormones / adverse effects
  • Adult
  • Ceftriaxone / administration & dosage
  • Ceftriaxone / therapeutic use*
  • Clinical Trials as Topic
  • Drug Interactions
  • Female
  • Follow-Up Studies
  • Humans
  • Injections, Intravenous
  • Lyme Disease / drug therapy*
  • Male
  • Middle Aged
  • Penicillins / administration & dosage
  • Penicillins / therapeutic use*
  • Prospective Studies
  • Random Allocation
  • Time Factors

Substances

  • Adrenal Cortex Hormones
  • Penicillins
  • Ceftriaxone