Abstract
23 patients with clinically active late Lyme disease were randomly assigned to intravenous treatment with either penicillin or ceftriaxone. Of the 10 treated with penicillin, 5 were judged treatment failures; of the 13 who received ceftriaxone, only 1 did not respond. An additional 31 patients were subsequently treated with ceftriaxone 4 g/day (n = 17) or 2 g/day (n = 14); success rates in both groups were comparable to those in the cohort randomised to ceftriaxone. Patients unresponsive to ceftriaxone were more likely to have received corticosteroid treatment.
Publication types
-
Clinical Trial
-
Comparative Study
-
Randomized Controlled Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Administration, Oral
-
Adrenal Cortex Hormones / adverse effects
-
Adult
-
Ceftriaxone / administration & dosage
-
Ceftriaxone / therapeutic use*
-
Clinical Trials as Topic
-
Drug Interactions
-
Female
-
Follow-Up Studies
-
Humans
-
Injections, Intravenous
-
Lyme Disease / drug therapy*
-
Male
-
Middle Aged
-
Penicillins / administration & dosage
-
Penicillins / therapeutic use*
-
Prospective Studies
-
Random Allocation
-
Time Factors
Substances
-
Adrenal Cortex Hormones
-
Penicillins
-
Ceftriaxone