Teicoplanin, its pharmacokinetics, blister and peritoneal fluid penetration

J Hosp Infect. 1986 Mar:7 Suppl A:47-55. doi: 10.1016/0195-6701(86)90007-1.

Abstract

The pharmacokinetics of a 440 mg iv dose of teicoplanin were studied in six male volunteers. The levels of the compound were measured microbiologically in serum, blister fluid and urine. The mean serum level 0-5 h after injection was 44.6 mg 1(-1), falling to 3.6 mg 1(-1) at 49 h. The serum elimination half-life of teicoplanin when fitted to a two-compartment model was 34.2 h; a three-compartment model gave a longer half-life. The apparent distribution half-life was 1.5 h. Penetration into cantharides induced blister fluid was moderately fast, the mean maximum concentration (14.8 mg 1(-1)) occurring at 2.7 h, the mean percentage penetration being 77.4%. Urinary recovery of the drug was 48.3% by 96 h. The drug penetrated rapidly into the non-inflammed peritoneal fluid of 34 patients undergoing elective surgery. The percentage penetration being 40% within the first hour, and 94.6% over the period of the study.

MeSH terms

  • Adult
  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / metabolism*
  • Ascitic Fluid / metabolism*
  • Blister / metabolism*
  • Glycopeptides / blood
  • Glycopeptides / metabolism
  • Humans
  • Injections, Intravenous
  • Kinetics
  • Male
  • Teicoplanin

Substances

  • Anti-Bacterial Agents
  • Glycopeptides
  • Teicoplanin