Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria

Lancet. 1986 Feb 22;1(8478):411-4. doi: 10.1016/s0140-6736(86)92371-8.

Abstract

6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Agranulocytosis / chemically induced*
  • Amodiaquine / administration & dosage
  • Amodiaquine / adverse effects*
  • Drug Combinations / administration & dosage
  • Drug Therapy, Combination
  • Female
  • Humans
  • Leukocyte Count
  • Malaria / prevention & control*
  • Male
  • Middle Aged
  • Neutropenia / chemically induced*
  • Proguanil / administration & dosage
  • Retrospective Studies
  • Sulfaguanidine / administration & dosage
  • Sulfamethoxazole / administration & dosage
  • Travel
  • Trimethoprim / administration & dosage
  • Trimethoprim, Sulfamethoxazole Drug Combination

Substances

  • Drug Combinations
  • Sulfaguanidine
  • Amodiaquine
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Trimethoprim
  • Sulfamethoxazole
  • Proguanil