Abstract
6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Adult
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Agranulocytosis / chemically induced*
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Amodiaquine / administration & dosage
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Amodiaquine / adverse effects*
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Drug Combinations / administration & dosage
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Drug Therapy, Combination
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Female
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Humans
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Leukocyte Count
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Malaria / prevention & control*
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Male
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Middle Aged
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Neutropenia / chemically induced*
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Proguanil / administration & dosage
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Retrospective Studies
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Sulfaguanidine / administration & dosage
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Sulfamethoxazole / administration & dosage
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Travel
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Trimethoprim / administration & dosage
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Trimethoprim, Sulfamethoxazole Drug Combination
Substances
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Drug Combinations
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Sulfaguanidine
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Amodiaquine
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Trimethoprim, Sulfamethoxazole Drug Combination
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Trimethoprim
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Sulfamethoxazole
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Proguanil