We report a case of infective endocarditis due to Cardiobacterium Hominis. This organism has rarely been recognized in the past as a human pathogen on the cardiac valves. This patient escaped early diagnosis, but he was successfully treated with parenteral ampicillin followed by elective aortic and mitral valve replacement. The bacteriological characteristics of this unusual cause of infective endocarditis are discussed and the world literature is reviewed.