Abstract
Here we report a case of carbapenem resistance in a human clinical isolate that was found to be closely related to the newly described environmental species Acinetobacter indicus. This strain harboured the blaOXA-23 carbapenemase gene located on a conjugative plasmid. Partial sequencing of 16S rDNA and rpoB genes, together with matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) analysis, showed that this strain was distantly related to the Acinetobacter baumannii-calcoaceticus complex and was closely related to A. indicus.
Keywords:
Acinetobacter; Carbapenemase; OXA-23; Taxonomy; β-Lactamase.
Copyright © 2014. Published by Elsevier B.V.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter / chemistry
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Acinetobacter / classification*
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Acinetobacter / drug effects*
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Acinetobacter / isolation & purification
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Acinetobacter Infections / microbiology*
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Anti-Bacterial Agents / pharmacology*
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Carbapenems / pharmacology*
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Cluster Analysis
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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DNA, Ribosomal / chemistry
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DNA, Ribosomal / genetics
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DNA-Directed RNA Polymerases / genetics
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Humans
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Male
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Molecular Sequence Data
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Phylogeny
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Plasmids
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RNA, Ribosomal, 16S / genetics
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Sequence Analysis, DNA
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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beta-Lactam Resistance*
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Carbapenems
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DNA, Bacterial
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DNA, Ribosomal
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RNA, Ribosomal, 16S
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DNA-Directed RNA Polymerases
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RNA polymerase beta subunit
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beta-lactamase OXA-23
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beta-Lactamases
Associated data
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GENBANK/KJ847272
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GENBANK/KJ847273
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GENBANK/KJ847274
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GENBANK/KJ847275
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GENBANK/KJ847276
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GENBANK/KJ847277