Carbapenem resistance in a human clinical isolate identified to be closely related to Acinetobacter indicus

Int J Antimicrob Agents. 2014 Oct;44(4):345-50. doi: 10.1016/j.ijantimicag.2014.05.022. Epub 2014 Jul 19.

Abstract

Here we report a case of carbapenem resistance in a human clinical isolate that was found to be closely related to the newly described environmental species Acinetobacter indicus. This strain harboured the blaOXA-23 carbapenemase gene located on a conjugative plasmid. Partial sequencing of 16S rDNA and rpoB genes, together with matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) analysis, showed that this strain was distantly related to the Acinetobacter baumannii-calcoaceticus complex and was closely related to A. indicus.

Keywords: Acinetobacter; Carbapenemase; OXA-23; Taxonomy; β-Lactamase.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter / chemistry
  • Acinetobacter / classification*
  • Acinetobacter / drug effects*
  • Acinetobacter / isolation & purification
  • Acinetobacter Infections / microbiology*
  • Anti-Bacterial Agents / pharmacology*
  • Carbapenems / pharmacology*
  • Cluster Analysis
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • DNA-Directed RNA Polymerases / genetics
  • Humans
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • Plasmids
  • RNA, Ribosomal, 16S / genetics
  • Sequence Analysis, DNA
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • beta-Lactam Resistance*
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • DNA, Bacterial
  • DNA, Ribosomal
  • RNA, Ribosomal, 16S
  • DNA-Directed RNA Polymerases
  • RNA polymerase beta subunit
  • beta-lactamase OXA-23
  • beta-Lactamases

Associated data

  • GENBANK/KJ847272
  • GENBANK/KJ847273
  • GENBANK/KJ847274
  • GENBANK/KJ847275
  • GENBANK/KJ847276
  • GENBANK/KJ847277