Successful treatment of osseous blastomycosis without pulmonary or disseminated disease and review of the literature

Diagn Microbiol Infect Dis. 2014 Jun;79(2):242-4. doi: 10.1016/j.diagmicrobio.2014.02.021. Epub 2014 Mar 7.

Abstract

Blastomycosis commonly occurs following inhalation of Blastomyces dermatitidis conidia causing a pulmonary infection and can disseminate to extrapulmonary sites. Osseous involvement primarily results from hematogenous spread, but in rare cases, direct inoculation can occur. We describe a case of osseous blastomycosis without pulmonary or disseminated disease successfully treated with posaconazole.

Keywords: Blastomycosis; Cutaneous inoculation; Orthopedic infection.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antifungal Agents / therapeutic use*
  • Blastomyces
  • Blastomycosis / diagnosis*
  • Blastomycosis / drug therapy*
  • Blastomycosis / microbiology
  • Blastomycosis / pathology
  • Bone Diseases / diagnosis*
  • Bone Diseases / drug therapy*
  • Bone Diseases / microbiology
  • Bone Diseases / pathology
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome
  • Triazoles / therapeutic use

Substances

  • Antifungal Agents
  • Triazoles
  • posaconazole