Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS

AIDS. 2012 Oct 23;26(16):2110-2. doi: 10.1097/QAD.0b013e328358daea.

Abstract

Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined. We describe three HIV-infected patients with corticosteroid-dependent and life-threatening paradoxical immune reconstitution inflammatory syndrome for whom thalidomide treatment induced rapid clinical remission and permitted complete corticosteroid withdrawal without clinical relapse.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy*
  • AIDS-Related Opportunistic Infections / immunology
  • Acquired Immunodeficiency Syndrome / drug therapy*
  • Acquired Immunodeficiency Syndrome / immunology
  • Adult
  • Antiretroviral Therapy, Highly Active
  • Female
  • Humans
  • Immune Reconstitution Inflammatory Syndrome / drug therapy*
  • Immune Reconstitution Inflammatory Syndrome / immunology
  • Immunosuppressive Agents / pharmacology*
  • Male
  • Meningitis, Cryptococcal / drug therapy*
  • Meningitis, Cryptococcal / immunology
  • Middle Aged
  • Recurrence
  • Steroids / therapeutic use
  • Thalidomide / pharmacology*
  • Treatment Outcome
  • Tuberculosis / drug therapy*
  • Tuberculosis / immunology

Substances

  • Immunosuppressive Agents
  • Steroids
  • Thalidomide