Abstract
Serum chloramphenicol and chloramphenicol succinate concentrations in patients given equivalent doses of chloramphenicol base either intravenously or orally for typhoid fever were measured by high-performance liquid chromatography. The mean serum chloramphenicol concentrations were significantly lower in the 11 patients treated with intravenous chloramphenicol succinate than in the 15 patients treated with oral chloramphenicol capsules.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Administration, Oral
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Adolescent
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Adult
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Child
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Chloramphenicol / administration & dosage
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Chloramphenicol / analogs & derivatives
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Chloramphenicol / blood*
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Chloramphenicol / therapeutic use
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Chromatography, High Pressure Liquid
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Female
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Humans
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Injections, Intravenous
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Male
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Middle Aged
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Typhoid Fever / blood*
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Typhoid Fever / drug therapy
Substances
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Chloramphenicol
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chloramphenicol succinate